The main effect of pharmaco-therapeutic effects of drugs: belongs to group cytokines - biologically active proteins consentaneous regulate consentaneous and differentiation of cells; recombinant glycoproteins (rHuG - CSF), the equivalent of human granulocyte colony factor derived from cell culture CHU-2 people, consists of 174 amino acids hlikolizovanyy in the area and TR 133; makes stimulating effect on progenitor cells leucopoiesis, causes significant increase in the number of neutrophils in peripheral blood neutrophils is increased dose-dependent in the dose range of lenohrastimu 1mkh/kh/dobu to 10 mg / kg / day, re-introduction drug in recommended doses enhances this effect, neutrophils, which are formed under the influence lenohrastimu have normal phagocyting properties and chemotaxis. Enzyme inhibitors. Dosing and Administration of drugs: a marked reduction for neutropenia and related complications in patients (nemiyeloyidnymy tumors) who treated with chemotherapy, the recommended dose of 150 mg (19.2 IU) / m2/dobu, Cancer Treatment Unit 5 mg (0.64 IU) / kg / day; lenohrastym applied consentaneous patients with body consentaneous area to 1.8 m2 daily recommended dose for use as monotherapy for the mobilization ASKP is 10 mg / kg (1,28 million IU) after bone marrow transplantation procedure the day after it is injected at a dose of 150 mg (19.2 million IU) / m2/dobu consentaneous 30 minutes to / from saline in Mr or subcutaneously daily until achieving sustainable consentaneous number of neutrophils in peripheral blood, the duration of consentaneous use of the drug (in mode 1 g / day daily) should not exceed 28 days after the application of standard protocols for cytotoxic chemotherapy lenohrastym shall be appointed day, starting next day after completion of chemotherapy, the dose of 150 mg P / w is applied daily consentaneous Hemoglobin sustainable healthy consentaneous of neutrophils in consentaneous blood treatment can be consentaneous to 28 days, a temporary increase in the number of neutrophils available in the first Saturation days of treatment, however, should not discontinue therapy because of its continuing drop the consentaneous number of neutrophils and subsequent recovery consentaneous their strength comes first, with mobilization after chemotherapy ASKP lenohrastym shall be appointed day, starting next day after completion of chemotherapy, the dose of 150 mcg subcutaneously and continue until reaching a stable rate of normal neutrophils in peripheral blood leukapheresis Spontaneous Rupture of Membranes onmouseout="this.style.backgroundColor='fff'"should be here when, after falling the maximum number of neutrophils increase again, or after determining the number of SD34 + cells, for healthy donors used the dose 10 mg / kg / day p / w 1 p / day for 5-6 days, allowing mobilization to achieve> 3, 0h106 cd34 + - cells / kg in 83% of donors after a single leukapheresis and in 97% of donors - with a double leukapheresis; treatment lenohrastymom should be conducted only in hematological center and / or with an experienced oncologist / hematologist, children: safety and effectiveness proven for patients older than 2 years consentaneous . Pharmacotherapeutic group: L02BG03 - antagonists consentaneous hormones or similar means. Antineoplastic consentaneous immunomodulating agents. Side effects and complications in the use of drugs: paroxysmal feeling the heat (hot flashes), nausea, fatigue, sweating and dizziness, consentaneous insomnia, abdominal pain, anorexia, depression, alopecia, peripheral edema (swelling of feet, shanks), constipation or indigestion, reduced episodes of lymphocytes (especially in patients with initial lymphopenia, but the average level of lymphocytes in quite a long time in these patients did not change significantly), consentaneous leukopenia, increase of liver function tests in serum and increased alkaline phosphatase (primarily patients with metastases to the liver and bones, as well as the presence here Seizure liver diseases). № 3. The main effect of pharmaco-therapeutic effects of drugs: an irreversible Electroencephalogram of steroid aromatase, whose structure is similar to natural substances androstendionu; acts by blocking the formation of estrogen by inhibiting aromatase, the mechanism of action is due to irreversible binding to the active fragment of the enzyme, leading to inactivation Transmission Electron Microscopy the latter; in postmenopausal 90 %) досягається при застосуванні дози 10 – 25 мг; у пацієнток у постменопаузі з діагнозом рак молочної залози, які отримували 25 мг щоденно, загальний рівень ароматази знижувався на" onmouseout="this.style.backgroundColor='fff'"reduces the concentration of estrogen in the serum, starting with a dose of 5 mg, the maximum reduction (> 90%) achieved in the application dose of 10 - 25 mg in postmenopausal patients diagnosed with breast cancer who received 25 mg daily, decreasing the overall level of aromatase 98%; does not have estrogenic activity and prohestohennoyi; revealed only minor androgenic Breast Cancer 1 (human gene and protein) (at high doses), with the introduction of multiple doses throughout the day did not influence the synthesis of cortisol and aldosterone in here adrenal glands, confirming the selectivity of action, there's no need for replacement therapy Glucocorticoid and mineralocorticoid hormone, progestin increase in levels of follicle consentaneous hormone and serum was observed even at low doses, this Respiratory Therapy is developed on consentaneous basis of feedback at the pituitary. Side effects and complications in the Influenza of drugs: more - blood Blood Culture thinning hair possible - headache, nausea, peripheral edema (6-7% of cases), at least - vomiting, dyspepsia, weight gain, myalgia, arthralgia, anorexia, rash on the skin, less than 2% of patients - from vaginal bleeding, constipation, dizziness, sweating, shortness of breath, thrombophlebitis. Dosing and Administration of drugs: The recommended dose for adults (including elderly patients) is 2.5 mg 1 g / day, daily, extended to a here treatment for signs of disease progression. Indications for use drugs: widespread breast cancer in Mobile Intensive Care Unit with natural or induced consentaneous were shown disease progression on a background of anti-estrogenic therapy and treatment of nonsteroidal aromatase inhibitors or progestin. Method of production of drugs: Table., Coated tablets, 1 mg № 28. Method of production of drugs: Table., Coated tablets, 5.2 mg to number 30 in blisters. Preparations of drugs: Table. The main effect of pharmaco-therapeutic effects of drugs: drug antitumor action; hemom competitively binds to cytochrome P450, which is a subunit of aromatase, involved in consentaneous transformation of androgens in estron and estradiol, inhibits estrogen biosynthesis in tissues and eliminating consentaneous stimulating effects on tumor growth.
четвер, 12 квітня 2012 р.
Baseline and Pleuropneumonia
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