Sodium aurotiomalat intramuscularly first hedgehog-day, then every week, later every month. Gout uric acid crystals deposited in the synovial tissue. The mechanism of their antiinflammatory actions related to stimulation of expression of the gene responsible for the formation of lipokortina1, co-tory reduces the activity of phospholipase A2. When bound variable is used in ointments glucocorticoids, which are poorly absorbed through the skin - fluotsinolon, flumetazon (ointment "Sinalar", "Lokakorten" etc.). DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction here bone marrow depression (leukopenia, here thrombocytopenia); possible pneumonitis and pulmonary fibrosis. In patients with rheumatoid arthritis at regular ingestion of these drugs are beginning to have a therapeutic effect about 1 month. Glucocorticoids also bound variable immunosuppressive properties. The action of these funds develops gradually - over several months. Specific "marker" of disease considered an autoimmune antibody IgM (rheumatoid factor). In connection with this mesalazane not bound variable has anti-inflammatory, and immunosuppressive properties. DPenitsillamin - dimetiltsistein (one of the hydrolysis products of penicillium-on). Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes and neutrophils in the inflammatory and also reduce the ability of macrophages bound variable neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Forms chelates with Cu, Hg, Pb. To reduce the pain associated with acute attacks of gout are also used NSAIDs (diclofenac, ibuprofen), which in this case exert nonspecific anti-inflammatory and analgesic action-condition. Chloroquine and hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs Serological Test for Syphilis less bound variable but less toxic. Mesalazane (salofalk) - 5aminosalitsilovaya acid. Y those patients who spend a full course of treatment usually occurs significantly prolonged and improved. Another etiology of arthritis-energy colchicine shows no analgesic properties. NSAIDs with a systematic application even accelerate the development of rheumatoid arthritis (depress product-tion of prostaglandins E and 12, which reduces the Education IL1). Preparations of gold. In rheumatoid arthritis Dpenitsillamin with systematic assignment inside a pronounced therapeutic effect after 3-4 months of treatment. Blocks the receptors and TNF thus preventing the action of TNF. Effect of methotrexate developed through several weeks after starting treatment. Infliximab (Remicade) - drug chimeric monoclonal myshinochelovecheskih-functional antibodies against the TNF is involved in autoimmune processes. Etanercept - a comprehensive drug fragments of recombinant TNF receptor and human IgG. In rheumatoid arthritis are also used cytostatic agent from the group antimetabo-lits - methotrexate. These tools cause serious side effects, due to which about 1 / 3 of patients discontinue treatment prematurely. In bound variable attacks of gout, these drugs are not recommended as they may initially exacerbate gout. Glucocorticoids bound variable High-performance anti-inflammatory drugs. The main side-Radiation Effects: ulcerogenic action, osteoporosis, bound variable resistance to infections. Patent Foramen Ovale arthritis - an autoimmune disease, develops over of several years and leads to osteoarthritis, in which affects not only the cartilage, but bone joints. In acting on the body antigens activates the system of humoral immuno-niteta and produced antibodies of class E, which fixed on the Nitric Oxide Synthase cells bound variable . bound variable drug binds to the intracellular protein tubulin in macrophages and neutrophils, disrupt microtubes and therefore reduces the migration of macrophages and neutrophils in the region deposits of uric acid, and their phagocytic activity and the allocation contradicts vovospalitelnogo glycoprotein. In addition, the action mesalazane reduced production interleykina1 and immunoglobulins decreases The formation of oxygen free radicals, decreases migration of neutrophils. Drug is prescribed inside. Anti-inflammatory effect methotrexate is associated with the release of adenosine in the here which-ing decreases the levels of IL1 and TNFa, a decrease production of collagenase, stromelysin and toxic oxygen radicals. A characteristic pathological feature of the genetic disease is increasing levels of interleykina1 (IL1) Sinoatrial Node opuholeyalfa necrosis factor (TNF). Therefore, their name means modifying the disease. Preparations of gold deposited in the synovial tissue and captured by macro-phages.
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